1/26/2024 0 Comments Translate pro statu isto![]() ![]() ![]() These men will be under investigation for possible prostate cancer, and will not have received a prostate biopsy previously.Īll men eligible for the study will have had a pre-biopsy MRI scan as part of the investigation for possible prostate cancer.Īfter obtaining informed consent they will be randomised to either a TRUS biopsy or an LATP biopsy.įollowing the biopsy procedure, the study team will follow up the men in order to determine the rate of detection of clinically significant prostate cancer (primary outcome) in each biopsy group. The TRANSLATE study aims to recruit 1042 men from at least 9 large Urology departments from United Kingdom Hospitals. The way in which urologists take biopsies for possible prostate has started to vary across the United Kingdom however, no level 1 evidence exists as to which method is best - both in terms of detecting clinically significant prostate cancer, and in terms of the occurrence of serious infection and other common side-effects of the biopsy process, along with patient tolerability, re-biopsy rate, and cost-effectiveness. However, local anaesthetic transperineal biopsy (LATP) has been pioneered in recent years, in order to sample the prostate gland via the perineum in the clinic, with the potential advantage that the transperineal approach to sampling reduces the risk of serious infection, and improves the sampling of the prostate gland (thus increasing the cancer detection), whilst avoiding the need for general anaesthetic in the operating theatre (as was the case for historical template prostate biopsies). ![]() Prostate biopsies have typically been taken via an ultrasound-guided transrectal approach (TRUS) under local anaesthetic in the clinic for several decades. These men may be offered a pre-biopsy MRI scan, followed by a prostate biopsy. 100,000 men each year in the United Kingdom are referred for investigation for possible prostate cancer based on an abnormal digital rectal examination of the prostate and/or an elevated age-specific PSA blood test. ![]()
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